Radiesse is very effective for treating moderate to deep facial wrinkles. For those who suffer from any facial flaws such as creases and folds around the mouth, eyes, or in between the eyebrows should consider Radiesse. Your medical professional may choose to numb that area with a cold pack or anesthetic cream prior to injecting. Discomfort is usually minimal and is only temporary. You can expect little to no downtime – which means you can return to work and continue throughout the course of your day. You may see a marked improvement in the moderate to severe frown lines between your brows and forehead within days. Improvement may continue for as long as a month and typically lasts up to a year.